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However, a landmark study showed that semaglutide could help people who are dangerously overweight reduce their risk substantially, to the point where their weight was no longer a health issue

A big study in the New England Journal of Medicine found that people taking semaglutide had an average weight loss of 14.9% from their starting weight, including data from healthy subjects

When switching from a longer-acting medication (semaglutide) to a shorter-acting one (tirzepatide), or vice versa, the gastric emptying pattern shifts, potentially altering absorption of concurrent oral medications

It is worth noting that clinical studies and post-marketing surveillance have identified an increased risk of gallbladder-related events with GLP-1 receptor agonists, including semaglutide, though the mechanism for this association is not fully understood